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Description
Monodisperse CoFe₂O₄ nanoparticles with an average core size of approximately 9 nm were synthesized by thermal decomposition and surface-engineered for magnetic particle hyperthermia. Polyacrylic acid (PAA) coating was employed to improve aqueous dispersibility and provide reactive groups for subsequent covalent attachment of lysine, tryptophan, and elastin via EDC/NHS coupling. The resulting nanoparticles were characterized using FTIR, DLS, SEM, TEM, XRD, and SQUID magnetometry to evaluate their surface chemistry, colloidal properties, morphology, crystal structure, and magnetic behavior. Magnetothermal performance was assessed through specific absorption rate (SAR) and intrinsic loss power (ILP). The results demonstrate that biomolecular functionalization modifies the interfacial and colloidal properties of CoFe₂O₄ nanoparticles while preserving their magnetic functionality, highlighting their potential as surface-engineered magnetothermal agents for magnetic hyperthermia.
