Speaker
Description
The precise delivery of bio-functionalized matters is of great interest in emerging biomedical technologies from the fundamental and applied viewpoints. Particularly, most existing single cell platforms are unable to achieve large scale operation with flexibility on cells and digital manipulation towards multiplex cell tweezers. Recently, the flexibility of magnetic shuttling technology using nano/micro-scale magnets for the circuitry manipulation of bio-carriers has gained significant advances for a versatile living cell manipulation tasks [1,2,3]. Herein, let’s call “spintrophoresis” using micro-/nano-sized Spintronic devices rather than “magnetophoresis” using bulk magnet. Especially analogy of IC chip via the electronic carriers of electron and hole has been implemented in the integrated spintrophoretic circuit platform with passive and active circuitry elements of collector, resistor, diode, capacitor and gating transistor of magnetic and pseudo-diamagnetic bio-carriers (mattertronics: matter+tronics), using remote magnetic actuation.
In fact, each cells have the heterogeneous bio-chemical characteristics, as well as different drug resistance. As for the realization of future personalized diagnosis and care considering the individual cell heterogeneity, primary hurdle is development of multiexed cell manipulation method. Here, magnetic assisted multiplexed cell array will offer the promising versatile platform for multiplexed cell tweezering, compared with the other methods including current FACS and optical tweezers. Here I will introduce the novel spintronic devices and their integrated platform for versatile multiplexed tweezers of living cells, which enables a portable multiplex cell manipulation platform for electro-bio-chemical analysis in individual cellular level.
Fig. 1 Magnetic potential energy over micro-magnetic pattern for magnetic and PsD holes [4].
Acknowledgments
This research was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean Government (MSIT) (2018R1A5A1025511).
References
[1] Y. Kang et al., “Tailored Micromagnet Sorting Gate for Simultaneous Multiple Cell Screening in Portable Magnetophoretic Cell‐On‐Chip Platforms,” Advanced Functional Materials. Wiley, Mar. 05, 2024. doi: 10.1002/adfm.202312875.
[2] H. Kim et al., “Magnetophoretic Decoupler for Disaggregation and Interparticle Distance Control,” Advanced Science, vol. 8, no. 12. Wiley, May 2021. doi: 10.1002/advs.202100532.
[3] B. Lim et al., “Magnetophoretic circuits for digital control of single particles and cells,” Nature Communications, vol. 5, no. 1. Springer Science and Business Media LLC, May 14, 2014. doi: 10.1038/ncomms4846.
[4] S. R. Goudu et al., “Mattertronics for programmable manipulation and multiplex storage of pseudo-diamagnetic holes and label-free cells,” Nature Communications, vol. 12, no. 1. Springer Science and Business Media LLC, May 21, 2021. doi: 10.1038/s41467-021-23251-4.
